60% is the founding base of your skin and is determined by your DNA
Your DNA makes you who you are. It tells you not only what care your skin needs, but also how your skin is prone to aging.
Your DNA does not lie and remains unchanged.
Our DNA products focus on your specific needs that result from your DNA profile. We gather this information with a DNA test. You can either order the DNA test seperately or order it in a package with your products.
How your DNA affects the ageing of your skin
By examining your DNA, we can gain more insights into your skin ageing process. In the lab we analyse several genes involved in collagen homeostasis, antioxidant protection, barrier function and skin hydration. Based on your DNA profile, we know what risks you are carrying and we develop products whose ingredients can counteract these risks.
Tissue damage by free radicals is one of the main causes of accelerated skin ageing. Free radicals are formed due to external stress factors, such as tobacco, pollution or exposure to UV radiation.
We have a natural 'built-in' protection mechanism since our skin itself produces antioxidants that can neutralise free radicals before they cause damage. But when this defensive mechanism does not function properly, traces of skin aging will be more visible.
Nomige investigates how well your defense mechanism works by detecting mutations in the antioxidant genes such as superoxide dismutase (SOD-2) and glutathione peroxidase (GPX).
Collagen is the most important structural protein of the extracellular matrix and is responsible for the firmness and elasticity of your skin. Collagen is created every time your skin renews itself (every 28 days). Sufficient production of collagen contributes to a beautiful and tighter skin.
Collagen is also broken down, this is a natural process. Breakdown or degradation can be accelerated under the influence of external stress factors such as UV light. It activates enzymes like matrix metalloproteinases (MMP) that 'eat away' the collagen. The balance between collagen production and degradation determines the velocity of the skin aging process.
When MMP genes show mutations or errors, they are "overactive" and break down collagen even faster. This creates an imbalance towards faster collagen breakdown which negatively affects the firmness and elasticity of your skin. We investigate mutations in different MMP genes and determine your risk of accelerated collagen degradation.
A well hydrated skin shows less wrinkles and is often less prone to irritation. A sensitive skin is the result of a disturbed skin barrier; one of which the intercellular lipids have some defects. As a result, not only irritants or allergens can penetrate the skin (from the outside to the inside), but water can also easily evaporate from the skin (from the inside to the outside). If this happens, skin dehydration occurs.
In addition, the moisture balance is also determined by molecules that can attract and transport water. Defects in these molecules also lead to a disturbed moisture balance and result in a dry, dehydrated skin.
Nomige investigates whether you have mutations in the genes that help keep the skin barrier intact and help control the moisture balance; namely Fillagrin (FLG) and Aquaporin-3 (AQ3)